In research that could give doctors a way to reassign sex in cases of unclear gender,
scientists report this that they have figured out why some children with genes
that should make them boys are instead born as girls.
The study, published in Nature, explains why some embryos with X and Y chromosomes—
which should be born as male—develop ovaries and eventually become girls.
The key is whether a gene called Sox9, involved in formation of the testes, is active.
"There are a surprisingly large number of cases where this process goes wrong,"
says Robin Lovell-Badge, a biologist at London's MRC National Institute for Medical Research."
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